Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous

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Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous

Given the importance of monocytes in pathogenesis of infectious and other inflammatory disorders, delineating functional and phenotypic characterization of monocyte subsets has emerged as a critical requirement. Although human monocytes have been subdivided into three different populations based on surface expression of CD14 and CD16, published reports suffer from contradictions with respect to...

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Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is known as immunosenescence and refers to the immune function deregulation. Therefore, functions o...

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Vasculitis are a heterogeneous group of disorders characterized by inflammation of the blood vessels of different caliber and sometimes fibrinoid necrosis with vessel wall destruction [1]. Vasculitis are divided into cutaneous and systemic forms, primary and secondary to hypertension, immunosuppression therapy, metabolic complications. The classification is based on the affected vessel size (Ta...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2015

ISSN: 2045-2322

DOI: 10.1038/srep13886